Vorinostat

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Product Name: Vorinostat

Other Names: Suberoylanilide Hydroxamic Acid, SAHA, Zolinza

CAS No.: 149647-78-9

Molecular Formula: C₁₄H₂₀N₂O₃

Specification: Purity ≥ 98%, complies with USP standards, available as a crystalline powder

Appearance and Color: White to off-white powder

Ingredient Information: Vorinostat is a synthetic histone deacetylase (HDAC) inhibitor developed from hydroxamic acid derivatives, typically synthesized via reaction of suberic acid with aniline followed by hydroxamation. Composed of carbon, hydrogen, nitrogen, and oxygen, it targets HDAC enzymes (Class I and II) with nanomolar potency, altering gene expression by increasing histone acetylation. It is processed into a stable, water-soluble crystalline powder for pharmaceutical and research applications.

Uses: Widely used in pharmaceuticals to treat cutaneous T-cell lymphoma (CTCL) in patients with progressive, persistent, or recurrent disease after two systemic therapies, approved by the FDA as Zolinza in 2006 for its ability to induce cancer cell apoptosis and arrest cell cycles. It is also explored in research for other cancers (e.g., mesothelioma, leukemia) and HIV eradication by reactivating latent virus reservoirs in combination therapies. Additionally, it serves as a tool in epigenetic studies to investigate gene regulation and cellular differentiation.