Trichostatin A

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Product Name: Trichostatin A

Other Names: TSA, (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

CAS No.: 58880-19-6

Molecular Formula: C₁₇H₂₂N₂O₃

Specification: ≥95% purity (HPLC), suitable for use as a histone deacetylase (HDAC) inhibitor in research applications

Appearance and Color: White to off-white powder

Ingredient Information: Trichostatin A is a potent and reversible inhibitor of HDACs, particularly class I and II enzymes, including HDAC1, HDAC3, HDAC4, and HDAC6. It acts as an epigenetic modifier by preventing the removal of acetyl groups from histone tails, thereby influencing gene expression and chromatin structure.

Uses: Trichostatin A is used in research to study gene regulation, cell differentiation, and the effects of histone acetylation. It has shown potential in cancer research by inducing apoptosis and cell cycle arrest in various cancer cell lines. Additionally, TSA has been investigated for its neuroprotective effects in models of neurodegenerative diseases such as amyotrophic lateral sclerosis.