application:It is an antitubercular, bacteriostatic drug.
description:Thiacetazone (TAC) is an inexpensive, antitubercular, bacteriostatic drug that has been widely used in combination with isoniazid in Africa and South America. Chemical analogues of TAC, SRI-224 and SRI-286, have been synthesized and tested against Mycobacterium avium and found to be more effective than TAC in vitro and in mice. We and others have recently shown that TAC is a prodrug that is activated by the mycobacterial monooxygenase EthA, which is also the activator of two other anti-tuberculosis drugs, ethionamide (ETH) and isoxyl (ISO). However, the mechanism of action of TAC remains an enigma. Our first observation on effects of TAC on M. bovis BCG was that it affects mycolic acid synthesis.
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