Monobenzone

Source high-purity Monobenzone (Hydroquinone Monobenzyl Ether), a specialized depigmenting agent and chemical intermediate. Ideal for pharmaceutical synthesis and industrial antioxidant applications. This crystalline powder offers consistent quality for B2B trade and manufacturing needs. Competitive pricing and reliable supply chain. High-quality raw material. Get a quote today!

Product Specification

• Product Name: Monobenzone (also known as 4-(Benzyloxy)phenol or Hydroquinone Monobenzyl Ether)
• Appearance: White to off-white crystalline powder; may appear amber upon exposure to light/air if not stabilized
• CAS No.: 103-16-2
• Molecular Formula: C₁₃H₁₂O₂
• Specification:
  • Purity: ≥ 98% or ≥ 99% (HPLC/GC, depending on grade)
  • Molecular Weight: 200.23 g/mol
  • Melting Point: 119–120 °C
  • Boiling Point: ~359 °C at 760 mmHg
  • Solubility: Practically insoluble in water; soluble in alcohol, ether, chloroform, and alkaline solutions
• Ingredient Information: INCI Name: Not commonly listed in standard cosmetic ingredient dictionaries for general consumer use due to its potent depigmenting nature. Chemically classified as an ether of hydroquinone. It acts as a melanin synthesis inhibitor and is primarily used in regulated pharmaceutical contexts for permanent depigmentation or as an industrial antioxidant intermediate.

Product Uses

Product Description:
Monobenzone is the monobenzyl ether of hydroquinone, distinguished by its ability to cause permanent depigmentation by destroying melanocytes. Unlike reversible skin lighteners, Monobenzone exerts a cytotoxic effect on pigment-producing cells, making it a critical active ingredient in medical treatments for extensive vitiligo, where uniform skin tone is achieved by depigmenting the remaining pigmented skin. Beyond dermatology, it serves as a valuable intermediate in organic synthesis and as an antioxidant stabilizer in polymer and rubber industries. Its high stability and specific reactivity make it a sought-after raw material for specialized pharmaceutical and chemical manufacturing.

Applications:
Monobenzone is utilized in highly regulated and specialized sectors, including:

• Pharmaceuticals: Formulation of topical prescription drugs for the treatment of severe vitiligo (e.g., Benoquin cream).
• Chemical Synthesis: Intermediate in the production of other fine chemicals, antioxidants, and polymer stabilizers.
• Industrial Antioxidants: Used in the stabilization of rubbers, plastics, and fuels to prevent oxidative degradation.
• Research & Development: Reference standard for dermatological studies involving melanocyte biology and pigmentation disorders.

Formulation Suggestions:
Recommended Usage: In pharmaceutical depigmenting creams, typical concentrations range from 20% to 25% w/w. For industrial antioxidant applications, usage levels vary significantly based on the substrate and required stability, often between 0.1% and 1.0%. Always adhere to strict regulatory guidelines for human application.

Method of Addition:

• Solubilization: Due to its poor water solubility, Monobenzone should be dissolved in suitable organic solvents (such as ethanol or propylene glycol) or incorporated into the oil phase of an emulsion before mixing with aqueous phases.
• Temperature: Can be added during the heating phase of emulsification (up to 70-80°C) as it is thermally stable within this range. Ensure complete dissolution to prevent crystallization upon cooling.

Compatibility & Synergy:

• Stabilizers: Requires protection from light and air to prevent oxidation. Use of antioxidants like Sodium Metabisulfite or EDTA in the formulation can enhance stability.
• Vehicle: Often formulated in hydrophilic ointment bases or alcohol-based gels to facilitate skin penetration. Compatible with common emollients and thickeners used in dermatological preparations.
• Incompatibilities: Avoid contact with strong oxidizing agents. Do not mix with ingredients that may cause excessive skin irritation or barrier disruption, as this may increase systemic absorption and adverse effects.
• Safety Note: Handling requires strict safety protocols due to the risk of permanent depigmentation upon accidental contact with healthy skin. Use appropriate PPE during manufacturing.