Levofloxacin Mesylate

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Product Name: Levofloxacin Mesylate

Other Names: Levofloxacin Methanesulfonate

CAS No.: 70458-95-6

Molecular Formula: N/A

Specification: Purity ≥ 98%, available as a crystalline powder, complies with pharmaceutical standards

Appearance and Color: White to yellowish crystalline powder

Ingredient Information: Levofloxacin Mesylate is a salt form of Levofloxacin, a third-generation fluoroquinolone antibiotic, synthesized by combining levofloxacin with methanesulfonic acid to enhance solubility over the base form. Composed of carbon, hydrogen, fluorine, nitrogen, oxygen, and sulfur, it retains levofloxacin’s broad-spectrum activity while improving water solubility (up to 100 mg/mL vs. 10 mg/mL for levofloxacin hemihydrate). It is processed into a stable, crystalline powder for use in pharmaceutical formulations.

Uses: Widely used in pharmaceuticals to treat bacterial infections like pneumonia, urinary tract infections, and sinusitis, acting by inhibiting DNA gyrase and topoisomerase IV, with MICs typically 0.03-2 µg/mL against susceptible pathogens (e.g., S. pneumoniae, E. coli). It is also employed in veterinary medicine for similar indications and in research for studying quinolone resistance mechanisms, though its use is tempered by black box warnings for tendon rupture and neuropathy risks since 2008. Additionally, it finds application in compounded formulations where higher solubility is advantageous.