Iguratimod

CAS: 123663-49-0
Molecular Formula: C17H14N2O6S
Molecular Weight: 374.37
Product description:1) Iguratimod for acute and chronic inflammation model (such as carageen glue in rats foot metatarsus swelling model, adjuvant induced arthritis) shows the effect of anti-inflammation and analgesia. (2) Iguratimod different from the traditional nonsteroidal anti-inflammatory drugs, of fasting rats has shown the digestive tract ulcer type of adverse reactions. (3) Iguratimod can suppress the inflammatory response induced by kaolin activated peptides The increase. (4) Iguratimod maude in inhibition of arachidonic acid cascade and selective cyclooxygenase 2 (cox-2) shape, can effectively inhibit fibroblasts in vitro release of prostaglandins, inflammatory reaction and reduce foot metatarsus swelling model rat inflammatory secretions of PGE2 in quantity, but does not affect the level of PG in the model rats of the digestive tract mucosa.