Fluticasone

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Product Name: Fluticasone

Other Names: Fluticasone Propionate, Flovent, Flixotide

CAS No.: 90566-53-3

Molecular Formula: C₂₂H₂₇F₃O₄S

Specification: Purity ≥ 98%, available as a white powder, complies with USP and EP standards

Appearance and Color: White to off-white powder

Ingredient Information: Fluticasone, commonly as Fluticasone Propionate, is a synthetic corticosteroid derived from fluticasone base via esterification with propionic acid, developed by GlaxoSmithKline in the 1980s. Composed of carbon, hydrogen, fluorine, oxygen, and sulfur, its trifluorinated structure enhances potency and reduces systemic absorption. It is processed into a stable, lipophilic powder with low water solubility (<0.1 mg/100 mL at 20°C), optimized for inhalation or topical delivery in pharmaceutical applications.

Uses: Widely used in pharmaceuticals as an anti-inflammatory and immunosuppressive agent in inhalers (e.g., Flovent) for asthma and COPD management, reducing airway inflammation at doses of 100-500 µg/day, and in nasal sprays (e.g., Flonase) for allergic rhinitis at 50-200 µg/day, approved by the FDA since 1990. It is also employed in topical creams for eczema and psoriasis, offering localized relief with minimal side effects due to low bioavailability (0.5% oral, 1-2% nasal). Additionally, it finds application in research for studying glucocorticoid receptor pathways and respiratory disease models.