Benfotiamine

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Product Name: Benfotiamine

Other Names: S-Benzoylthiamine O-Monophosphate, Vitamin B1 Derivative

CAS No.: 22457-89-2

Molecular Formula: C₁₉H₂₃N₄O₆PS

Specification: Purity ≥ 98%, available as a white crystalline powder, complies with USP standards

Appearance and Color: White to off-white crystalline powder

Ingredient Information: Benfotiamine is a synthetic, fat-soluble derivative of thiamine (vitamin B1), developed in Japan in the 1950s to enhance bioavailability. Composed of carbon, hydrogen, nitrogen, oxygen, phosphorus, and sulfur, it features a thiamine core modified with a benzoyl group, allowing it to penetrate lipid membranes more effectively than water-soluble thiamine. It is processed into a stable, crystalline powder that converts to active thiamine in the body, achieving up to five times higher blood levels than thiamine HCl.

Uses: Widely used in dietary supplements to support nerve health, alleviate neuropathic pain, and improve glucose metabolism, particularly in managing diabetic neuropathy and peripheral nerve damage, with clinical studies showing reduced pain scores at 600 mg/day over 6 weeks. It is also employed in research for its potential to reduce advanced glycation end-products (AGEs), supporting cardiovascular and cognitive health, and in functional foods for its antioxidant properties. Additionally, it finds application in cosmetics for its anti-inflammatory benefits in skin formulations.