Ursodeoxycholic Acid

Source high-purity Ursodeoxycholic Acid (UDCA), a premium secondary bile acid widely utilized in pharmaceutical and cosmetic formulations. Renowned for its cytoprotective, anti-inflammatory, and choleretic properties, it is the gold standard for treating cholestatic liver diseases and is increasingly valued in skincare for soothing and barrier repair. Ideal for manufacturers of hepatoprotective drugs and advanced dermocosmetics. High-quality raw material. Get a quote today!

Product Specification

• Product Name: Ursodeoxycholic Acid (UDCA / Ursodiol)
• Appearance: White crystalline powder
• CAS No.: 128-13-2
• Molecular Formula: C₂₄H₄₀O₄
• Specification: Purity ≥99.0% (HPLC); Molecular Weight: 392.57 g/mol; Melting Point: 200–204°C; Loss on Drying: <1.0%; Specific Rotation: +59° to +62°
• Ingredient Information: Natural hydrophilic bile acid; Poorly soluble in water, soluble in alcohol and glacial acetic acid; Epimer of chenodeoxycholic acid; USP/EP grade available

Product Description

Ursodeoxycholic Acid (UDCA) is a naturally occurring hydrophilic bile acid that stands out for its unique ability to protect cells from toxicity induced by more hydrophobic bile acids. In the pharmaceutical sector, it is the first-line therapy for primary biliary cholangitis (PBC) and gallstone dissolution, leveraging its choleretic and immunomodulatory effects. In the cosmetic industry, UDCA has emerged as a sophisticated active ingredient for sensitive and inflamed skin. It effectively reduces inflammation, strengthens the skin barrier, and mitigates irritation caused by environmental stressors or harsh actives. Its dual role as a critical therapeutic agent and a gentle, restorative cosmetic ingredient drives consistent global demand across both medical and beauty markets.

Product Uses

This ingredient is primarily used in the manufacturing of pharmaceutical preparations, including capsules, tablets, and oral suspensions, for the treatment of liver disorders such as primary biliary cholangitis, primary sclerosing cholangitis, and cholesterol gallstones. In the cosmetic and personal care industry, UDCA is incorporated into soothing serums, creams, and masks designed for sensitive, rosacea-prone, or compromised skin. It helps reduce redness, calm inflammation, and improve skin hydration. Additionally, it is explored in hair care products for its potential to support scalp health and reduce inflammation associated with hair loss conditions. It also serves as a key reference standard in biochemical research studying bile acid metabolism and cell signaling pathways.

Formulation Recommendation

Recommended Usage Level: For cosmetic applications, typical usage levels range from 0.1% to 1.0% w/w, depending on the desired soothing effect. In pharmaceutical solid dosage forms, content is strictly regulated based on therapeutic dosage (e.g., 250 mg per capsule).
Addition Method: Due to poor water solubility, UDCA should be dissolved in a suitable solvent such as ethanol, propylene glycol, or polysorbate before incorporation into aqueous phases. For emulsions, it can be added to the oil phase if solubilized appropriately. Micronization is recommended for solid formulations to enhance dissolution and bioavailability. Ensure complete dissolution to prevent crystallization in the final product.
Compatibility: Compatible with most cosmetic emollients, humectants, and soothing agents like allantoin and bisabolol. Stable in neutral to slightly acidic pH ranges. Avoid strong alkaline conditions which may lead to salt formation and altered solubility. Synergizes well with other barrier-repair ingredients such as ceramides and fatty acids. Protect from light and moisture during storage.