Thymidine
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Product Name: Thymidine
Other Names: Deoxythymidine, 2'-Deoxythymidine, Thymine Deoxyriboside
CAS No.: 50-89-5
Molecular Formula: C₁₀H₁₄N₂O₅
Specification: Purity ≥ 99%, available as a white crystalline powder, complies with USP standards
Appearance and Color: White to off-white crystalline powder
Ingredient Information: Thymidine is a pyrimidine nucleoside naturally occurring in DNA, composed of thymine (a pyrimidine base) linked to a deoxyribose sugar via a β-N1-glycosidic bond, synthesized industrially through microbial fermentation or chemical coupling of thymine with deoxyribose derivatives. Composed of carbon, hydrogen, nitrogen, and oxygen, it is water-soluble (50 g/L at 20°C) and stable under neutral conditions but degrades in strong acids or bases. It is processed into a stable, crystalline powder for research and pharmaceutical applications.
Uses: Widely used in molecular biology research as a precursor for DNA synthesis, supporting cell culture growth (e.g., 0.1-1 mM in media) and labeling studies with radiolabeled thymidine (e.g., [³H]-thymidine) to track DNA replication. It is also employed in pharmaceutical development for antiviral drugs (e.g., zidovudine synthesis) and in research for studying nucleotide metabolism and DNA repair mechanisms. Additionally, it finds application in biotechnology for producing thymidine analogs and in diagnostic assays for proliferation studies, though high doses can inhibit DNA synthesis competitively.
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