Tetracosactide

Source high-purity Tetracosactide, a synthetic analog of adrenocorticotropic hormone (ACTH) essential for diagnostic and therapeutic pharmaceutical applications. This potent peptide stimulates cortisol production, serving as a critical tool for assessing adrenal function and treating specific inflammatory conditions. Ideal for manufacturers of diagnostic kits and specialized injectables. High-quality raw material. Get a quote today!

Product Specification

• Product Name: Tetracosactide (Synthetic ACTH 1-24)
• Appearance: White to off-white lyophilized powder
• CAS No.: 16960-16-0
• Molecular Formula: C₁₃₆H₂₁₀N₄₀O₃₁S
• Specification: Purity ≥98.0% (HPLC); Molecular Weight: ~2933.5 g/mol; Acetate Content: <5.0%; Water Content: <5.0%; Single Impurity: <1.0%
• Ingredient Information: Synthetic polypeptide comprising the first 24 amino acids of natural ACTH; Soluble in water and dilute acetic acid; Sterile filtration recommended for parenteral use

Product Description

Tetracosactide is a synthetic peptide corresponding to the biologically active N-terminal 24-amino acid sequence of human adrenocorticotropic hormone (ACTH). It retains full potency in stimulating the adrenal cortex to secrete glucocorticoids, mineralocorticoids, and androgens. Its primary value lies in its standardized activity and stability compared to natural extracts, making it the gold standard for diagnostic testing of adrenal insufficiency (Addison's disease). In therapeutic settings, it offers a targeted approach for managing conditions like infantile spasms and multiple sclerosis exacerbations by modulating endogenous steroid production. The demand for high-quality Tetracosactide remains steady in both clinical diagnostics and specialized neurology treatments, driven by its reliability and precise mechanism of action.

Product Uses

This ingredient is predominantly used in the manufacturing of diagnostic agents for the Synacthen test (or ACTH stimulation test), which assesses the functional reserve of the adrenal glands. It is formulated into injectable solutions for intravenous or intramuscular administration in hospital and clinical laboratory settings. Therapeutically, Tetracosactide is incorporated into pharmaceutical preparations for treating infantile spasms (West syndrome) in pediatric patients and for managing acute exacerbations in multiple sclerosis when corticosteroids are contraindicated or ineffective. It is also utilized in endocrinology research to study hypothalamic-pituitary-adrenal (HPA) axis dynamics and steroidogenesis mechanisms.

Formulation Recommendation

Recommended Usage Level: For diagnostic injections, typical single doses range from 0.25 mg (250 mcg) to 1 mg, depending on the protocol (standard vs. low-dose test). For therapeutic use in infantile spasms, dosing is weight-based and strictly regulated.
Addition Method: Reconstitute lyophilized powder with sterile saline or water for injection immediately before use. For stable liquid formulations, dissolve in acetate buffer (pH 4–5) containing preservatives like benzyl alcohol if multi-dose vials are intended. Filter sterilize through a 0.22 μm membrane.
Compatibility: Compatible with standard isotonic agents like sodium chloride and mannitol. Avoid mixing with strong oxidizing or reducing agents. Stable in acidic to neutral pH ranges; degradation accelerates at alkaline pH. Store lyophilized product at 2–8°C; protect reconstituted solutions from light and heat, using within 24 hours to maintain potency.