Solnatide

Source high-purity Solnatide, a novel synthetic peptide agonist of the epithelial sodium channel (ENaC) designed for advanced pulmonary research. This innovative compound promotes alveolar fluid clearance and lung edema resolution, making it an essential tool for studying acute respiratory distress syndrome (ARDS) and lung injury mechanisms. Ideal for laboratories focused on respiratory physiology and critical care therapeutics. High-quality raw material. Get a quote today!

Product Specification

• Product Name: Solnatide (Research Grade)
• Appearance: White to off-white lyophilized powder
• CAS No.: Not publicly assigned (Proprietary synthetic peptide; often referenced by development code AP301)
• Molecular Formula: C₁₆₈H₂₇₄N₅₀O₄₉S₄ (Approximate, based on specific sequence variants)
• Specification: Purity ≥98% (HPLC); Molecular Weight: ~4.2 kDa; Endotoxin <1.0 EU/mg; Sterile filtered options available
• Ingredient Information: Synthetic peptide analog of human Tumor Necrosis Factor (TNF); Specifically engineered to activate ENaC without pro-inflammatory effects

Product Description

Solnatide is a groundbreaking synthetic peptide that selectively activates the epithelial sodium channel (ENaC) in alveolar type II cells. Unlike native TNF, which triggers widespread inflammation, Solnatide is structurally modified to retain only the fluid-clearing properties, effectively stimulating sodium transport and subsequent water reabsorption from the alveolar space. This mechanism is critical for resolving pulmonary edema, a hallmark of conditions like Acute Respiratory Distress Syndrome (ARDS). In preclinical studies, it has demonstrated significant efficacy in improving oxygenation and reducing lung water content without inducing systemic inflammatory responses. As a research tool, Solnatide offers a unique opportunity to investigate novel therapeutic pathways for lung injury, providing a precise molecule for exploring the balance between fluid homeostasis and immune regulation in the respiratory system.

Product Uses

This ingredient is strictly intended for laboratory research and preclinical studies. It is widely used in respiratory physiology research to investigate mechanisms of alveolar fluid clearance and lung edema resolution. Scientists utilize Solnatide in ex vivo lung perfusion models and animal models of ARDS to evaluate its impact on gas exchange and lung compliance. Additionally, it serves as a key reagent in cell-based assays using alveolar epithelial cell lines to study ENaC channel activity, ion transport kinetics, and signal transduction pathways involved in lung fluid balance. It is not approved for human consumption or clinical use outside of regulated trials.

Formulation Recommendation

Reconstitution: Dissolve in sterile deionized water or PBS containing 0.1% BSA to prevent adsorption. Gentle vortexing is recommended. Prepare stock solutions at 1–5 mg/mL. Aliquot and store at -80°C.
Usage Concentration: In vitro, typical concentrations range from 1–100 nM for cell culture assays measuring ion current or fluid transport. In ex vivo lung models, concentrations of 1–10 μg/mL are often applied via aerosolization or instillation.
Compatibility: Compatible with standard physiological buffers and cell culture media. Avoid repeated freeze-thaw cycles. For aerosol delivery studies, ensure formulation is isotonic and pH-neutral to maintain peptide stability and bioactivity in the lung environment.