PTD-DBM

Source high-purity PTD-DBM Peptide, a specialized bioactive peptide designed to target the Wnt/β-catenin signaling pathway for advanced hair care and regenerative applications. This innovative ingredient inhibits CXXC5 to promote follicle health and stimulate growth. Ideal for premium anti-hair loss serums and scalp treatments. Competitive bulk pricing for cosmetic and pharmaceutical manufacturers. High-quality raw material. Get a quote today!

Product Specification

• Product Name: PTD-DBM Peptide (Protein Transduction Domain - Dishevelled Binding Motif)
• Appearance: White to off-white lyophilized powder
• CAS No.: 1609454-11-6
• Molecular Formula: C₁₂₄H₂₂₅N₆₁O₂₈S₂
• Specification:
  • Purity: ≥ 95% or ≥ 98% (HPLC)
  • Molecular Weight: 3082.64 g/mol
  • Acetate Content: ≤ 12.0%
  • Water Content: ≤ 8.0%
  • Peptide Content: ≥ 80.0%
  • Endotoxin: ≤ 50 EU/mg
• Ingredient Information: INCI Name: Not yet universally standardized; often listed as "sh-Oligopeptide-2" or under proprietary trade names in cosmetic registries. It is a cell-penetrating peptide conjugate consisting of a Protein Transduction Domain (PTD) linked to a Dishevelled Binding Motif (DBM). Functionally acts as a CXXC5-Dvl protein-protein interaction inhibitor.

Product Uses

Product Description:
PTD-DBM is a cutting-edge bioactive peptide that addresses hair loss at the cellular level by modulating the Wnt/β-catenin signaling pathway. By inhibiting the CXXC5 protein, a negative regulator of this pathway, PTD-DBM helps reactivate dormant hair follicles and extends the anagen (growth) phase. Its unique structure includes a Protein Transduction Domain (PTD) that enhances cellular uptake, ensuring efficient delivery of the active motif into target cells. This ingredient represents a significant advancement in non-invasive hair restoration technologies, offering a scientific approach to combating androgenetic alopecia and promoting denser, healthier hair.

Applications:
PTD-DBM is primarily utilized in specialized personal care and dermatological products, including:

• Anti-Hair Loss Serums & Tonics: Leave-on treatments for scalp application to stimulate follicle activity.
• Scalp Care Essences: Pre-shampoo or overnight treatments aimed at improving scalp environment and hair density.
• Medical Aesthetic Products: Post-procedure care formulations to support hair regeneration after clinical treatments.
• Advanced Shampoos & Conditioners: Rinse-off or leave-in products formulated for thinning hair concerns.

Formulation Suggestions:
Recommended Usage: Typically used at low concentrations due to high potency. Common usage levels range from 0.01% to 0.1% of the pure peptide powder in the final formulation, depending on the specific supplier's activity data.

Method of Addition:

• Phase: Add during the cool-down phase (below 40°C / 104°F) to preserve peptide integrity. Avoid high heat which can denature the protein structure.
• Solubility: Soluble in water and aqueous buffers. Ensure complete dissolution before adding to the main batch. Pre-dissolving in a small amount of distilled water or glycol is recommended.

Compatibility & Synergy:

• pH Stability: Maintain formulation pH between 5.0 and 7.0 for optimal stability and skin compatibility.
• Synergistic Ingredients: Works well with other hair growth supporters such as Biotin, Niacinamide, Caffeine, and plant extracts like Saw Palmetto or Ginseng. Can be combined with moisturizing agents like Hyaluronic Acid for improved scalp hydration.
• Preservation: Ensure robust preservation system as peptide solutions can be susceptible to microbial growth. Avoid strong oxidizing agents.
• Chelating Agents: Inclusion of EDTA or similar chelators can help stabilize the peptide by sequestering metal ions.