Nemifitide

Source high-purity Nemifitide, a potent synthetic tachykinin receptor antagonist peptide for advanced neuroscience and pain research. This selective NK3 receptor blocker offers precise modulation of neurokinin pathways, making it ideal for studying depression, anxiety, and chronic pain mechanisms. Essential for laboratories developing novel CNS therapeutics. High-quality raw material. Get a quote today!

Product Specification

• Product Name: Nemifitide (Research Grade)
• Appearance: White to off-white lyophilized powder
• CAS No.: 189106-56-7
• Molecular Formula: C₅₈H₇₆N₁₂O₁₃
• Specification: Purity ≥98% (HPLC); Molecular Weight: ~1133.3 g/mol; Sequence: H-Tyr-D-Trp-Gly-Phe-Met-Pro-Leu-Arg-NH₂ (or specific analog variant); Endotoxin <1.0 EU/mg
• Ingredient Information: Synthetic octapeptide; Tachykinin NK3 receptor antagonist; Soluble in DMSO or aqueous buffers with carrier protein

Product Description

Nemifitide is a specialized synthetic peptide that acts as a selective antagonist of the neurokinin-3 (NK3) receptor. By blocking the binding of endogenous tachykinins like neurokinin B, it modulates key neurotransmitter systems involved in mood regulation, stress response, and pain perception. Its high affinity and selectivity make it a valuable tool for investigating the role of the tachykinin system in central nervous system disorders. In preclinical research, Nemifitide has shown promise in models of depression and anxiety, offering a non-monoaminergic mechanism of action. This distinct profile positions it as a critical compound for exploring novel therapeutic avenues beyond traditional SSRIs and benzodiazepines, particularly for treatment-resistant conditions.

Product Uses

This ingredient is strictly intended for laboratory research and preclinical studies. It is widely used in neuroscience research to investigate the physiological roles of NK3 receptors in the brain and spinal cord. Scientists utilize Nemifitide in animal models of depression, anxiety, and chronic pain to evaluate behavioral responses and neurochemical changes. Additionally, it serves as a key reagent in receptor binding assays and cell-based signaling studies to characterize NK3 antagonist potency and specificity. It is also employed in pharmacokinetic studies to assess peptide stability and blood-brain barrier penetration. It is not approved for human consumption or clinical use outside of regulated trials.

Formulation Recommendation

Reconstitution: Dissolve in sterile deionized water or PBS containing 0.1% BSA to prevent adsorption. For initial solubilization, a small volume of DMSO may be used if necessary, followed by dilution in aqueous buffer. Gentle vortexing is recommended. Prepare stock solutions at 1–5 mg/mL. Aliquot and store at -80°C.
Usage Concentration: In vitro, typical concentrations range from 1 nM to 1 μM for cell culture assays measuring intracellular calcium flux or cAMP levels. In vivo, dosing in rodent models often ranges from 0.1–10 mg/kg via intraperitoneal or subcutaneous injection, depending on the behavioral paradigm.
Compatibility: Compatible with standard physiological buffers. Avoid repeated freeze-thaw cycles. Stable in acidic to neutral pH ranges. For behavioral studies, ensure vehicle controls match the solvent composition (e.g., saline with minimal DMSO) to avoid confounding effects.