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Larazotide

Larazotide is a high-purity zonulin antagonist peptide for intestinal barrier research. High-quality raw material. Get a quote today!

Product Specification

Product Name: Larazotide Acetate
Appearance: White to off-white lyophilized powder
CAS No.: 881851-50-9 (Acetate); 258818-34-7 (Base)
Molecular Formula: C32H55N9O10
Specification: ≥98.0% (HPLC)
Ingredient Information: Synthetic Octapeptide (Zonulin Antagonist)

Product Uses

Larazotide is a synthetic octapeptide that acts as a selective inhibitor of zonulin, a key modulator of intestinal tight junctions. By preventing the opening of these junctions, it restores intestinal barrier integrity and reduces paracellular permeability. Primarily investigated for the treatment of celiac disease as an adjunct to a gluten-free diet, it mitigates gluten-induced inflammation and symptoms. Its mechanism also shows promise for other conditions involving barrier dysfunction, such as inflammatory bowel disease (IBD) and type 1 diabetes. In research and pharmaceutical development, it serves as a critical tool for studying gut permeability and developing targeted therapies for autoimmune and inflammatory disorders.

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