Emodepside

Source high-purity Emodepside, a potent depsipeptide anthelmintic active ingredient for advanced veterinary pharmaceutical development. This novel compound targets nematode neuromuscular junctions, offering superior efficacy against resistant parasites in companion animals. Ideal for formulating next-generation deworming solutions and combination therapies. High-quality raw material. Get a quote today!

Product Specification

• Product Name: Emodepside (Veterinary Grade)
• Appearance: White to off-white crystalline powder
• CAS No.: 259048-76-1
• Molecular Formula: C₅₄H₇₄N₈O₁₆S₂
• Specification: Purity ≥98.5% (HPLC); Molecular Weight: ~1131.3 g/mol; Loss on Drying: <0.5%; Residual Solvents: Compliant with ICH guidelines
• Ingredient Information: Synthetic cyclic depsipeptide; Octadepsipeptide structure containing amino acids and hydroxy acids; Insoluble in water, soluble in organic solvents like DMSO and methanol

Product Description

Emodepside is a groundbreaking anthelmintic agent belonging to the depsipeptide class, specifically engineered to combat gastrointestinal nematodes in veterinary medicine. Its unique mechanism of action involves activating latrophilin-like receptors and SLO-1 potassium channels in parasites, leading to flaccid paralysis and death. This distinct pathway ensures efficacy against strains resistant to traditional benzimidazoles, macrocyclic lactones, and levamisole. As pet ownership rises and demand for effective parasite control grows, Emodepside stands out for its broad-spectrum activity against roundworms, hookworms, and whipworms. It is frequently combined with praziquantel to provide comprehensive protection against both nematodes and cestodes, making it a critical component in modern veterinary parasitology and pharmaceutical innovation.

Product Uses

This ingredient is primarily used in the manufacturing of veterinary anthelmintic formulations for companion animals, particularly cats and dogs. It is a key active component in topical spot-on solutions and oral tablets designed for the treatment and control of gastrointestinal parasites. Emodepside is extensively utilized in products targeting multi-resistant nematode infections, including Ancylostoma tubaeforme, Toxocara cati, and Trichuris vulpis. Additionally, it is incorporated into combination therapies with praziquantel to offer broad-spectrum protection against tapeworms and roundworms simultaneously. Its application is strictly limited to veterinary use and is not intended for human consumption or agricultural livestock treatment.

Formulation Recommendation

Recommended Usage Level: Typically formulated at concentrations ranging from 1% to 3% w/w in topical solutions, depending on the target species and dosage volume.
Addition Method: Dissolve Emodepside in a suitable organic solvent or co-solvent system (e.g., propylene glycol, ethanol, or DMSO) before blending with other vehicle components. Ensure complete dissolution prior to adding hydrophilic phases if creating emulsions. For solid oral forms, micronize the powder to enhance bioavailability and mix uniformly with excipients.
Compatibility: Highly compatible with praziquantel for synergistic broad-spectrum effects. Stable in non-aqueous environments; avoid exposure to strong acids or bases which may degrade the depsipeptide bond. Use antioxidants if formulating with oxidation-prone carriers. Ensure final formulation protects against photodegradation if packaging is transparent.