ACE-031

Source high-purity ACE-031, a potent research-grade activin receptor type IIB fusion protein. Designed for advanced biomedical studies on muscle growth and bone density, this recombinant protein offers exceptional bioactivity and consistency. Ideal for laboratories investigating myostatin inhibition and metabolic disorders. High-quality raw material. Get a quote today!

Product Specification

• Product Name: ACE-031 (Activin Receptor IIB-Fc Fusion Protein)
• Appearance: White to off-white lyophilized powder
• CAS No.: Not applicable (Recombinant protein; no single CAS number)
• Molecular Formula: N/A (Complex protein structure; Approx. MW: ~75-80 kDa)
• Specification: Purity ≥95% (SDS-PAGE); Endotoxin <1.0 EU/μg; Formulated in sterile PBS
• Ingredient Information: Recombinant human Activin Receptor IIB extracellular domain fused to human IgG1 Fc region; Expressed in CHO cells

Product Description

ACE-031 is a sophisticated recombinant fusion protein that acts as a decoy receptor for myostatin and other TGF-beta superfamily members. By inhibiting these negative regulators of muscle growth, ACE-031 promotes significant increases in muscle mass and strength in preclinical models. Its high affinity and specificity make it a valuable tool for researching sarcopenia, muscular dystrophy, and bone density loss. As the field of regenerative medicine expands, ACE-031 stands out for its potential to address unmet needs in muscle-wasting conditions, offering researchers a robust molecule for exploring therapeutic avenues in metabolic and neuromuscular diseases.

Product Uses

This ingredient is strictly intended for laboratory research and preclinical studies. It is widely used in muscle biology research to investigate the mechanisms of myostatin signaling and muscle hypertrophy. Scientists utilize ACE-031 in animal models of muscular dystrophy, cachexia, and age-related muscle loss to evaluate efficacy in preserving lean mass. Additionally, it serves as a critical reagent in bone metabolism studies, exploring its role in enhancing bone density and strength. It is not approved for human consumption or clinical use.

Formulation Recommendation

Reconstitution: Reconstitute in sterile deionized water or PBS to a concentration of 0.1–1.0 mg/mL. Gentle pipetting is recommended to avoid foaming. Aliquot and store at -80°C.
Usage Concentration: Typical dosing in vivo ranges from 1–10 mg/kg, depending on the animal model and study duration. In vitro, use concentrations of 10–100 ng/mL for cell culture assays.
Compatibility: Compatible with standard physiological buffers. Avoid repeated freeze-thaw cycles. For stability, add carrier proteins like BSA (0.1%) if diluting to low concentrations. Store protected from light.