4-Hydroxyisoleucine

Source high-purity 4-Hydroxyisoleucine, a unique amino acid derived from fenugreek seeds, renowned for its potent insulinotropic activity. This natural ingredient effectively supports glucose metabolism and muscle health, making it a premium choice for dietary supplements targeting diabetes management, sports nutrition, and weight control. Ideal for manufacturers seeking evidence-based functional ingredients. High-quality raw material. Get a quote today!

Product Specification

• Product Name: 4-Hydroxyisoleucine (4-HIL)
• Appearance: White crystalline powder
• CAS No.: 15025-86-2
• Molecular Formula: C₆H₁₃NO₃
• Specification: Purity ≥98.0% (HPLC); Molecular Weight: 147.17 g/mol; Loss on Drying: <0.5%; Heavy Metals: <10 ppm; Arsenic: <2 ppm
• Ingredient Information: Non-proteinogenic amino acid isolated from Trigonella foenum-graecum; Highly water-soluble; Stable at room temperature; Typically produced via extraction or biosynthesis

Product Description

4-Hydroxyisoleucine (4-HIL) is a distinctive non-proteinogenic amino acid primarily found in fenugreek seeds. It is highly valued for its ability to stimulate insulin secretion in a glucose-dependent manner, meaning it enhances insulin release only when blood glucose levels are elevated, thereby minimizing the risk of hypoglycemia. This mechanism makes it an exceptional ingredient for managing type 2 diabetes and metabolic syndrome. Beyond glycemic control, 4-HIL promotes lipid metabolism and supports muscle recovery by enhancing glucose uptake into muscle cells. Its natural origin, combined with robust clinical evidence supporting its efficacy in regulating blood sugar and improving insulin sensitivity, drives its growing popularity in the nutraceutical and functional food markets.

Product Uses

This ingredient is widely used in the manufacturing of dietary supplements designed for blood sugar support, including capsules, tablets, and powders targeted at individuals with prediabetes or type 2 diabetes. In the sports nutrition sector, 4-HIL is incorporated into pre-workout and recovery formulations to enhance muscle glucose uptake, improve energy utilization, and support lean mass maintenance. It is also utilized in functional foods and beverages, such as low-glycemic snacks and health drinks, aimed at weight management and metabolic health. Additionally, 4-HIL serves as a key component in anti-obesity formulations, leveraging its role in regulating lipid metabolism and appetite control.

Formulation Recommendation

Recommended Usage Level: Typical effective dosages range from 500 mg to 1000 mg per serving in dietary supplements. For functional foods, inclusion levels should be adjusted to deliver equivalent daily doses.
Addition Method: Highly water-soluble; easily dissolved in aqueous phases for liquid formulations or blended uniformly with dry ingredients for capsules and tablets. Ensure homogeneous mixing to guarantee consistent dosing.
Compatibility: Compatible with most vitamins, minerals, and herbal extracts. Synergizes well with other glucose-regulating agents like chromium picolinate, berberine, and alpha-lipoic acid. Stable in neutral to slightly acidic pH environments. Avoid exposure to extreme heat during processing to prevent degradation. Store in a cool, dry place to maintain stability and prevent clumping.