What is Nicorandil?
Nicorandil is a baby atom KATP (Kir6) approach opener, bearing alleviation of coronary vascular bland muscle. Specific bounden of Nicorandil to the C-terminus of the SUR2B K(ATP) approach generates K+ alteration and hyperpolarization of the apparent membrane, bearing consistent cease of voltage-dependent ion channels and abridgement of intracellular chargeless Ca2+. Nicorandil stimulates guanylate cyclase and increases circadian GMP levels in alternation with the activation of K(ATP) channels. Nicorandil is aswell declared to abolish mitochondrial permeability alteration triggered by oxidative accent consistent from ischemia-reperfusion, preventing mitochondrial calcium uptake/overload and oxidative damage. Nicorandil has aswell been apparent to serve as a nitric oxide donor.
Nicorandil is acclimated abiding to administer angina. It is usually acclimated as monotherapy.