Can Pyrantel Pamoate Be A Raw Material？
Pyrantel pamoate is an anti-parasitic infection compound as well as depolarizes muscle neuro-blockers.
Pyrantel pamoate can be used to treat helminth infections (pinworms, hookworms, etc.) because it blocks the neuromuscular junction and prevents worm movement (and then the parasite is expelled by peristaltic movement). Its pharmacological action involves inhibition of cholinesterase.
Pyrantel pamoate is used for the treatment of intestinal nematode infections, particularly for hookworm and ascaris infection. However, it's ineffective for trichuriasis. Pyrantel take effects by targeting the nicotinic acetylcholine receptor on the surface of nematode somatic muscle, thereby depolarizing the neuromuscular junction of the nematode, causing irreversible paralysis and natural expulsion of the worm. Resistance is related to a modification of the nicotinic receptor. Pyrantel pamoate is poorly absorbed in the intestine; over 85% of the dosage is passed unchanged in feces. The absorbed portion is metabolized and excreted in urine. It is usually effective in a single dosage. Safety in pregnancy and children younger than 2 years has not been worked out. It has minimum toxicity at doses used to treat intestinal helminth infection. Reported side-effects are usually limited to anorexia, nausea, vomiting, abdominal cramps, and diarrhea. Pyrantel has been proved to increase theophylline contents. The related drug oxantel has recently been demonstrated to enhance the activity of albendazole against T. trichuria.
Pyrantel pamoate is used as a deworming agent for the treatment of hookworms (all species) and roundworms (Parascaris equorum, also known as ascarids in human bodies) for domestication of animals such as horses, cattle, sheep, pigs, cats, dogs and many other species. It is a combination of pyrantel and pamoic acid. Some pharmaceutical companies have paired pyrantel pamoate with praziquantel for tapeworms, and sometimes febantel couples with whipworms to provide more complete treatment for intestinal parasites in one dose. It is also been used in pinworm treatment for humans in many brands, including "Reese's Pinworm Medicine", "Pin-X", "Pin-Rid", "Combantrin", "Anthel", "Helmintox", and "Helmex". Pyrantel pamoate is also usually included in monthly used chewable heartworm tablets for cats and dogs.
The drug is used to treat intestinal helminth infections such as needle worms, ascarids and hookworms. Pyrantel belongs to a class of drugs known as anthelmintics. Its role is to disable the worms from moving (namely paralysis) so that the body can naturally remove them in the faeces.