Suramin

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Product Name: Suramin

Other Names: Suramin Sodium, Germanin, Bayer 205

CAS No.: 145-63-1

Molecular Formula: C₅₁H₄₀N₆O₂₃S₆

Specification: Purity ≥ 98%, available as a crystalline powder, complies with pharmaceutical standards

Appearance and Color: White to slightly yellow powder

Ingredient Information: Suramin is a synthetic polysulfonated naphthylurea, first developed by Bayer in 1916 from trypan blue derivatives, created by Oskar Dressel and team. Composed of carbon, hydrogen, nitrogen, oxygen, and sulfur, its complex structure with six sulfonic acid groups and multiple aromatic rings enables it to disrupt parasite metabolism. It is processed into a water-soluble sodium salt powder for intravenous administration, known for its long half-life of 41-78 days.

Uses: Widely used in pharmaceuticals to treat early-stage African trypanosomiasis (sleeping sickness) caused by Trypanosoma brucei rhodesiense and gambiense, administered IV to kill parasites by inhibiting energy metabolism, approved by WHO as an essential medicine. It is also employed historically for onchocerciasis (river blindness), though less common now due to toxicity concerns, and in research for its potential against cancers (e.g., prostate), viral infections (e.g., HIV), and autism via the cell danger response hypothesis, though not FDA-approved for these uses outside trials.