Pregabalin

Pregabalin

CAS NO.: 148553-50-8
Molecular Formula: C8H17NO2
Molecular weight: 159.229
Appearance: White to off-white crystalline powder  
Assay Content by HPLC:  Min. 98%-101%
Specific Rotation:  + 10° ~+12°
Chloride:  ≤ 0.1 %
Mesh size:  100% pass 80mesh            
Solubility:  Soluble in Ethanol
Loss on drying %: ≤ 1.0 %
Heavy metals:  ≤20 PPM
Application: 
Be used in food pharmaceutical and cosmeceutical
Main Function:
1. Pharmacological efficacy: Pregabalin is a novel γ-aminobutyric acid (GABA) receptor agonist, can block the voltage-dependent calcium channels to reduce neurotransmitter release.
2. The main clinical for the treatment of peripheral neuropathic pain as well as part of adjuvant treatment of focal seizures.
3. Treatment of epilepsy in developing the most promising drug in a drug treatment better and more convenient administration.Pregabalin can also be used to treat pain and anxiety.
Description: 
Pregabalin is a 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.
Shelf Life:  Two years if sealed and stored away from direct sun light.    
Packing & Storage:  Store in cool & dry place. Keep away from strong light and heat.

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