Molecular Formula: Nodakenin
Molecular Weight: 408.3992
Product description:Nodakenin is a coumarin compound initially isolated from the roots of Angelica gigas. In the present study, we investigated the effects of nodakenin on learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) using the passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Nodakenin (10 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in the passive avoidance test and the Y-maze test (P<0.05), and also reduced escape latency during training in the Morris water maze test (P<0.05). Moreover, swimming times and distances within the target zone of the Morris water maze were greater in the nodakenin-treated group than in the scopolamine-treated group (P<0.05). In an in vitro study, nodakenin was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC(50)=84.7 microM). In addition, nodakenin was also found to inhibit acetylcholinesterase activity for 6 h in an ex-vivo study. These results suggest that nodakenin may be a useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, via the enhancement of cholinergic signaling.
Please at any time if you are interested in Nodakenin.
If you want to know about Nodakenin price , please call our Customer Services Hotline +86 592 5365887 or send the email to email@example.com.
We sincerely welcome friends from all over the world to contact us. After sending an online inquiry, we will reply to you as soon as possible. If you do not get any response on time please call us.
We are committed to meeting customers' unique needs by providing comprehensive and professional service, enjoying a good reputation among our business partners and customers for high-quality products, excellent after-sales services, competitive prices, and prompt shipping.
Shanghai Office: 168 Zhonggu Rd, Pingpu District, Shanghai, China.
Xiamen Office: 106, Houdaixi Road, Xiamen, China.
Tel: +86 592 5365887
Mobile phone: +86 189 6515 7632
E-mail:firstname.lastname@example.org(Reply within 1 working day)
WhatsApp/QQ/Skype/Mob: +86 13696950872
Our VP sales manager has over 25 years of management experience in all leadership roles.
WhatsApp/QQ/Skype/Mob: +86 17306002753
Estella Zeng is responsible for all lead generation, customer service, and marketing operations.
WhatsApp/QQ/Skype/Mob: +86 18965157632
Jerry Bai is responsible for the global sales, service and channel expansion into the European market.
Supplying safe and efficient ingredients and formulas for cosmetic and nutritional products.
Offering the best product design to customers with natural and high-quality raw materials.
Honesty Profession Win-win Cooperation