Nalidixic acid is the first of the synthetic quinolone antibiotics. Technically, it is a naphthyridone, not a quinolone: its ring structure is a 1, 8-naphthyridines nucleus that contains two nitrogen atoms, not quinoline, which has a single nitrogen atom .
Nalidixic acid is used to treat urinary tract infections due to gram-negative bacteria. Although the nalidixic acid (NegGram) drug label does not specifically mention genetic testing, the FDA highlight precaution labeling prior to initiating treatment with nalidixic acid for G6PD deficient individuals due to an association with hemolytic anemia.
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