CAS Number: 159351-69-6
Molecular Weight: 958.22
Molecular Formula: C53H83NO14
Application: An inhibitor of FRAP (mTOR)
Storage: Store at -20° C
Everolimus is a macrolide derived from Rapamycin (sc-3504) and shown to inhibit cell proliferation induced by growth factors. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Studies indicate that Everolimus is a FRAP (mTOR) inhibitor that displays high affinity toward the intracellular receptor FKBP12. Additionally, the Everolimus-FKBP12 complex decreases the activity of the S6K1 and 4EBP by binding to FRAP.
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