CAS Number: 877399-52-5
Molecular Weight: 450.34
Molecular Formula: C21H22Cl2FN5O
Solubility: Soluble in DMSO (25 mg/mL warming), ethanol (25 mg/mL warming), methanol, and chloroform. Insoluble in water.
Storage: Store at -20° C
Application: A Met inhibitor effective against various cell lines
Crizotinib shows inhibition of Met phosphorylation in mIMCD3 mouse of MDCK canine epithelial cells with an IC50 of 5 nM and 20 nM, respectively, as well as NCI-H69 and HOP92 cells, with an IC50 of 13 nM and 16 nM, respectively. Crizotinib shows a near-equivalent IC50 of 24 nM against the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncogenic fusion varient of the ALK RTK expressed by the KARPAS299 human anaplastic large-cell lymphoma (ALCL) cell line. Crizotinib supresses human GTL-16 gastric carcinoma cell growth with an IC50 of 9.7 nM. Crizotinib induces apoptosis in GTL-16 cells with an IC5050 of 30 nM.
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