Aliskiren

Aliskiren

CAS : 173334-57-1
Mol. Formula : C30H53N3O6
Mol. mass : 551.758
Product Description : Aliskiren (INN) is the first in a class of drugs called direct renin inhibitor. Its current licensed indication is primary (previously essential) hypertension.
Use :
Aliskiren is a minor substrate of CYP3A4 and, more important, P-glycoprotein:
1.duces furosemide blood concentration. 
2.orvastatin may increase blood concentration, however no dose adjustment needed. 
3.ssible interaction with cyclosporin ( the concomitant use of cyclosporin and aliskiren is contraindicated). 
4.ution should be exercised when aliskiren is administered with ketoconazole or other moderate P-gp inhibitors (itraconazole, clarithromycin, telithromycin, erythromycin, amiodarone). 

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