Molecular weight:414.495 g/mol
7-Hydroxymitragynine, an indole, is an active alkaloid in the plant Mitragyna speciosa, commonly known as Kratom. It has opioid agonistic activity. "The potency, calculated using pD values, was 30- and 17-fold higher than that of mitragynine and morphine, respectively. Antagonism of naloxone on concentration-response curves for 7-hydroxymitragynine confirmed its opioid effect. These results suggest that the opioid effect of M. speciosa is mostly based on the activity of 7-hydroxymitragynine."
7-Hydroxymitragynine is orally active in animals as an analgesic, and produces normal opioid side effects including constipation development of tolerance and withdrawal syndrome upon abstinence.The O-acetyl ester, 7-acetoxymitragynine has also been reported and found to be an active μ-opioid agonist.
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