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What is Spilanthol?

CAS: 25394-57-4

Molecular Formula: C14H23NO
Molecular weight:221.33900
Density:0.896g/cm3
Boiling point:384.7°C
Flash point:234°C
Shelf life:2 years
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What is Annonacin?

CAS: 111035-65-5

Purity:99%
Storage:Avoid exposure to sunlight,Keep dry
Description
Annonacin is extracted from the annonaceous plant. i.e. pawpaw fruit contains a high concentration of Annonacin, which is toxic to cortical neurons. Annonacin induced growth arrest and apoptosis in ERα-related pathways in MCF-7 cells. Moreover, Annonacin attenuated MCF-7 xenograft tumor growth while inhibiting ERα, cyclin D1 and Bcl-2 protein expressions in nude mice. Annonacin-induced ATP depletion causes the retrograde transport of mitochondria to the cell soma and induces changes in the intracellular distribution of tau in a way that shares characteristics with some neurodegenerative diseases. Annonacin caused significant cell death in various cancer cell lines. T24 bladder cancer cells at the S phase were more vulnerable to the cytotoxicity of Annonacin. Furthermore, Annonacin activated p21 in a p53-independent manner and arrested T24 cells at the G1 phase. It also induced Bax expression, enhanced caspase-3 activity, and caused apoptotic cell death in T24 cells.
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What is Tannic acid used for

Tannic acid is used in the conservation of ferrous (iron based) metal objects to passivate and inhibit corrosion. Tannic acid reacts with the corrosion products to form a more stable compound, thus preventing further corrosion from taking place. After treatment the tannic acid residue is generally left on the object so that if moisture reaches the surface the tannic acid will be rehydrated and prevent or slow any corrosion. Tannic acid treatment for conservation is very effective and widely used but it does have a significant visual effect on the object, turning the corrosion products black and any exposed metal dark blue. It should also be used with care on objects with copper alloy components as the tannic acid can have a slight etching effect on these metals.

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