Zopiclone

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[ Author: B&K Views: () Posted at: 31/03/2010]

Zopiclone

Product name : Zopiclone

CAS : 43200-80-2

Molecular formula : C17H17ClN6O3

Molecular Weight : 388.81

Product description :   
This medicine is a hypnotic agent used to treat sleep disorders.

Pharmacology :
The pharmacological profile of zopiclone is similar to that of the benzodiazepines.
In sleep laboratory studies of 1 to 21-day duration in man, zopiclone reduced sleep latency, increased the duration of sleep and decreased the number of nocturnal awakenings. Zopiclone delayed the onset of REM sleep but did not reduce consistently the total duration of REM periods. The duration of stage 1 sleep was shortened, and the time spent in stage 2 sleep increased. In most studies, stage 3 and 4 sleep tended to be increased, but no change and actual decreases have also been observed. The effect of zopiclone on stage 3 and 4 sleep differs from that of the benzodiazepines which suppress slow wave sleep. The clinical significance of this finding is not known.
Some manifestations of rebound insomnia have been reported both in sleep laboratory and clinical studies following the withdrawal of zopiclone.
At the clinically recommended dose of 7.5 mg, peak plasma concentration of 60 ng/mL is achieved within 90 minutes.

Indications and usage :
The short-term management of insomnia is characterized by difficulty in falling asleep, frequent nocturnal awakenings and early morning awakening.



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