Sequence: Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr(Cys1&Cys6,Cys2&Cys10, Cys5&Cys13 bridge)
CAS NO.: 851199-59-2
Molecular Formula: C59H79N15O21S6
Molecular Weight: 1526.74
Appearance: White powder
The intestinal and intestinal secretion-promoting effects of this drug and the improvement of colonic hyperalgesia are thought to contribute to the improvement of bowel movement abnormalities and abdominal pain, abdominal discomfort in constipation-type irritable bowel syndrome.
Linaclotide is a 14-amino acid peptide that is a uridine cyclase C receptor agonist in intestinal epithelial cells. Experiments have shown that the drug promotes fluid secretion and transport.
Linaclotide is used to treat irritable bowel syndrome with constipation and chronic constipation with no known cause.
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