Combretastatin A4 disodium phosphate(CA4P)

Combretastatin A4 disodium phosphate(CA4P)

Synonym:Fosbretabulin disodium
Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol dihydrogen phosphate disodium salt
CAS NO.:168555-66-6
Molecular Formula:C18H19Na2O8P 
Molecular Weight: 440.30
Melting Point: 238-242 °C
Boiling Point: 611.8 °C at 760 mmHg
Solubility: Soluble in Methanol
Appearance:White or off-white powder
Description About Combretastatin A4 disodium phosphate(CA4P) CAS 168555-66-6:
Combretastatin A4 disodium phosphate(CA4P) is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities.
In addition, Combretastatin A4 disodium phosphate(CA4P) can increase the permeability of endothelial cells while inhibiting their migration and suppress capillary tube formation via disruption of VE-cadherin. 
Furthermore, Combretastatin A4 disodium phosphate(CA4P) can change the morphology of endothelial cells by altering their tubulin cytoskeleton. Combretastatin A-4 phosphate (fosbretabulin) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.

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